Contacts and Staff

CNRS Core Research Facility
Science B 230
1 Harpst Street
Arcata, CA 95521
Phone: 707.826.3272
Email: cnrs.core@humboldt.edu

Staff

David S. Baston, Ph.D.

Academic Background:

Ph.D. (2009) Agricultural and Environmental Chemistry, University of California – Davis, Davis, CA

M.S. (2002) Soil Science/Chemistry, University of California – Davis, Davis, CA

B.S. (1995) Environmental Toxicology, University of California – Davis, Davis, CA

My Bachelor and Master of Science focused on Fate and Transport of anthropogenic compounds in environmental and biological systems. During this time I also held a Student Hydrologist position at the U.S.G.S. in Sacramento working as an analytical chemist for the Toxic Substances and NAWQA programs evaluating water, groundwater, sediment, soil, and atmospheric samples for Current Use and Legacy pesticides. My Doctorate work integrated my previous environmental toxicology experience with cellular/molecular biology and signal transduction. This work included development and validation, and use of multiple Bioassays designed to provide a high-throughput semi-quantitative analysis of POPs in the environment. Additional postdoctoral work focused on signal transduction using a NSCLC cell line to model, identify, quantitate, and determine efficacy of Tyrosine Kinase Inhibitors on cigarette smoke induced lung cancer; isolating and identifying novel compounds from nutraceuticals and their contribution towards inhibiting Prostate Cancer. I remain interested in the processes causing toxic insult in both environmental and human settings and the changes in cellular signaling pathways leading to aberrant cellular function.

Select Publications

Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells. Mol Cancer Ther. 2013 May 17, 1029.

CALUX Measurements: Statistical Inferences for the Dose Response Curve. Talanta 2011, Sep. 30;85(4):2039–46.

Third Generation Ah Receptor-Responsive Luciferase Reporter Plasmids: Amplification of Dioxin Responsive Elements Dramatically increases CALUX Bioassay Sensitivity and Responsiveness. Toxicol. Sci.2011, Jul. 20 (Epub).

Considerations for Potency Equivalent Calculations in the Ah Receptor-Based CALUX Bioassay: Normalization of Superinduction Results for Improved Sample Potency Estimation. Talanta, 15;83(5):1415–21, 2011. 

Atmospheric Transport of Pesticides in the Sacramento, California, Metropolitan Area, 1996–1997.  Michael S. Majewski and David S. Baston; USGS, Water Resources Investigation Report 02-4100, Jul. 2002.

David Baston